I tell my clients that that question provides a perfect opportunity for them to reiterate their qualifications for the job. So, I recommend their response is a statement of their qualification for each of the major requirements of the job.  It's the verbal equivalent of a T letter. 

For example, the requirements for one job were:
* Experience working with diverse populations
* Microsoft Office
* Internet 
* Excellent communications and interpersonal skills
* Familiar with community resources
* Understanding barriers to employment

The response I suggested was:
“I have experience working successfully with diverse populations as an Employment Counselor in several different settings. I am proficient using Word, Excel, and PowerPoint, and at internet use for all aspects of job search and application, having done these things virtually every day for the past five years. I have proven my effectiveness at communication throughout a career as a Project Manager, Staff Manager, and successful Employment Counselor, writing countless and varied documents as well as doing orientations for groups and teaching job search and retention skills. My interpersonal skills have been developed in team leadership and various other positions and through interactions with very diverse stakeholders. I have a long list of community programs that help unemployed people in a wide range of areas and a list of free training programs. I have helped people with many barriers to employment and am sensitive to the fact that these barriers can add significant stress to the otherwise-stressful position of being out of work. I also understand that these issues may lead to negative perceptions from employers and it is my job to counter those perceptions. Finally, I am passionate about helping people find jobs: I have walked in their shoes and I know what it’s like.”

That answer takes about a minute 60-75 seconds to deliver and that form of reply has been well received. Just an alternative to think about.